Endocrine Abstracts

During the last three decades the number of patients with diabetes mellitus (DM) type 2 have increased, which is associated with an increase in the prevalence of obesity among the world’s population. DM type 2 and obesity are closely linked with the production of leptin by adipose tissue. Diseases of the thyroid gland (TG) as well as type 2 DM are the most common endocrine pathologies. Many studies have found an increase of antithyroid antibodies titers against the backg...

Introduction: Decrease in thyroid hormones (TH) levels is associated with reduced blood flow to kidneys and decreased glomerular filtration rate (GFR) along with alteration of tubular reabsorption.Deiodinase type 1 is an enzyme that is active in liver and kidneys and plays an important role in TH metabolism.The aim of the research was to study the dependence of markers of renal function on C/T polymorphism in the DIO 1 gene in pati...

IntroductionObesity is an important medical and social problem of our time, because its prevalence is growing rapidly and affects about 30% of the adult population of the planet. Obesity is characterized by an increase in the expression of cytokines that cause endothelial damage. It is known that prohormone thyroxine (T4) is converted into 5 times more active triiodothyronine (T3) in peripheral organs (such as live...

Background: Among the heterogeneous types of diabetes mellitus (DM), latent autoimmune diabetes in adults (LADA) is the most common and attracts the attention of scientists, the pathogenesis of which combines the main mechanisms of classical type 1 (T1DM) and type 2 diabetes mellitus (T2DM). The role of hyperamylinemia in the development and progression of LADA remains out of the researchers’ attention.The objective: of the study was to determine th...

Background: Chronic kidney disease (CKD) is one of the leading causes of disability and mortality in patients with different types of diabetes mellitus (DM). However, relationships between kidney function and serum amylin levels are still controversial, especially in patients with heterogeneous types of diabetes. The objective of the study was to determine the features of the glomerular filtration rate (GFR) in patients with DM depending on the level of amylinemia.<p class...

Background: Metabolic syndrome is a cluster of conditions (abdominal obesity, atherogenic dyslipidemia, hypertension, insulin resistance with or without glucose intolerance) that occur together, increasing risk of cardiovascular diseases.The objective: Of the study was to determine components of metabolic syndrome in patients with diabetic kidney disease (DKD) depending on the phenotype of LADA.Methods: 42 patients with LADA (19 pa...

Background: Chronic pyelonephritis (CP) is a common kidney infection complication in patients with diabetes mellitus and one of the main reasons of chronic kidney disease in diabetic patients.The objective: Of the study was to determine the features of the carbohydrate metabolism and insulin resistance in patients with CP depending on the phenotype of latent autoimmune diabetes in adults (LADA).Methods: 28 patients with LADA and CP...

IntroductionVitamin D deficiency is recognized as a global problem worldwide. Today, there is information about the relationship between vitamin D levels and the pathogenetic links in the development of classic forms of diabetes mellitus (DM). In particular, vitamin D deficiency has been shown to cause insulin deficiency, progression of insulin resistance, and β-cell dysfunction. There is growing evidence that vitamin D deficiency may be a risk fact...

The aim of this study was to assess thyroid homeostasis in patients with liver cirrhosis (LC) of non-viral etiology and analyze the association between serum thyroid parameters and A/C polymorphism in the deiodinase type 1 (DIO1) gene in these patients.Material and Methods: The study was conducted on 70 subjects: 50 patients with (LC) and 20 healthy controls. The thyroid homeostasis was evaluated by using «thyroid function tests», measurement o...

Introduction: Chronic kidney disease (CKD) is one of the leading causes ofdisability and mortality in patients with diabetes mellitus. Existence of specific phenotypes of diabetic kidney disease (DKD) is established nowadays. The prevalence of the classic albuminuric phenotype has decreased by 24% over the past decade (NHANES).The purpose of our work was to investigate the phenotypic features of DKD depending on the type of diabetes.<p class="abstext...